Meredith and Derek hooked up on the very first episode of Grey's Anatomy, and through thick, thin and post-it note weddings, they've been the focal point of the show ever since.
Which is why we've left the Grey's core couple out of the poll below. MerDer is in a league of its own at this point, while the show's other romantic pairings are all relatively knew.
Since the beginning of last season, we've met Drs. Arizona Robbins and Owen Hunt, Lexie and Mark coupled up and Alex and Izzie got married. Love is in the air at Seattle Grace!
Executive Producer Krista Vernoff says the show has spent a lot of time getting people together, and now it's time to tell stories of people being together. Amen to that, we say.
But besides MerDer, whose stories are you most excited to see told in this new season and beyond? Which of the four Grey's Anatomy couples below is your favorite? Vote!
Which Grey's Anatomy couple is your favorite?