L. Scott Caldwell portrayed Rose Nadler, the cancer patient cured by the island on Lost. Come February 23, we'll see if Seattle Grace has similar healing powers.

Or, more accurately, her husband will. Caldwell will play the wife of a patient taking part in the Alzheimer’s clinical trial Derek's running on Grey's Anatomy.

Interestingly enough, Caldwell’s Lost better half Bernard was played by Sam Anderson, who appeared on Grey's Anatomy himself in February 2009.

Grey's is all new tonight. Click here for promos and sneak peeks.

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