Well, this is nice and ominous.

ABC sources have confirmed the Grey's Anatomy Season 10 premiere title to TV Line and it may not bode well for the future of Dr. Richard Webber.

The September 26th opener will be called "Seal Our Fate." Gulp.

As previously reported, the two-hour opener will center on the new interns at the hospital, as well as the aftermath of Meredith's difficult birth.

We also know that Veronica Cartwright will guest star on the premiere, as will Bobby Campo and Heather Hemmens. The former's role is unknown, while the latter pair will portray an engaged couple who viewers meet at the scene of an accident.

Grey's Anatomy Season 10 will feature a quartet of new series regulars. Gaius Charles, Jerrika Hinton, Camilla Luddington and Tessa Ferrer were all promoted by the hit drama in June. They all debuted on Season 9 as the characters of Shane, Stephanie, Jo and Lea, respectively.

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.