It looks like NCIS isn't the only CBS hit that will be losing a major player this fall.

CBS sources have confirmed to TV Line that Amanda Righetti and Owain Yeoman will be exiting The Mentalist toward the end of Season 6.

Will the departures of Van Pelt and Rigsby be connected to the reveal of Red John, which has been promised to take place before 2013 concludes?

Creator Bruno Heller simply says his drama is heading into “most dramatic and game changing season and anything can happen.”.

In possibly related news, The Mentalist - which returns with new episodes on September 29 - will be introducing a new female series regular in 2014.

Sound off on all these shakeups now!

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.