Lex Luthor, who is portrayed by Michael Rosenbaum, was a series regular on Smallville from the first season until the seventh.  Lex, of course, grows up to be Superman's infamous arch-nemesis.

Lex Luthor Quotes

But if you look at history the great men and women of the world have always been defined by their enemies.

Lex

Lex: Clark...do you believe a man can fly?
Clark: Sure. In a plane.
Lex: No, I'm not talking about that. I'm talking about soaring through the clouds, with nothing but air beneath you.
Clark: People can't fly, Lex.
Lex: I did. After the accident, when my heart stopped. It was the most exhilarating two minutes of my life. I flew over Smallville, and for the first time, I didn't see a dead end. I saw a new beginning. Thanks to you, I have a second chance. We have a future, Clark, and I don't want anything to stand in the way of our friendship.

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Smallville Quotes

But if you look at history the great men and women of the world have always been defined by their enemies.

Lex

Clark: Isn't it time we moved beyond these mental trials?
Jor-El: Your determination is strong, Son, but just as your passion will be your greatest strength, so, too, will it be your greatest obstacle.