Regina Newly is Samantha's mother.

This is one narcissistic housewife. She has very strong feelings about Oprah Winfrey and the Home and Garden Channel. Regina is actually excited about Samantha's amnesia, as she can use it to fix her relationship with her daughter, and to mold Sam into the perfect offspring. 

Regina Newly Quotes

Dena: (about Samantha) She's a bridesmaid!
Regina: In a wedding?
Dena: Yeah.
Regina: You mean someone liked her?
Samantha: Yes mother, it is possible despite my upbringing.

Regina: You're never gonna make it sweetheart.
Samantha: No? Watch me. Somebody likes me and it's an honor to be asked and I'm not gonna let down my good friend Victoria.
Dena: Valerie.
Samantha: Whatever.

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Samantha Who? Quotes

Sam: Couple of good things about being in a coma: no fattening food, lots of rest, they sponge you down every day. It's like a spa. Bad things: my nose itches, I have something called the "Pina Colada Song" stuck in my head, and, oh yeah, sometimes I can hear what people in my room are saying.

Sam: Good things about amnesia: all new clothes, no re-runs. Bad: every minute is like that dream where you haven't been to class all year, and the test is now.