Amelia is back on Grey's Anatomy. And she's working here with Derek.

Wait... huh? Who?!? What?!? Derek and Meredith are a tad taken aback in this Grey's Anatomy scene.

This is one of the cutest photos ever of Mer and Der. It is from the Grey's Anatomy episode "Change of Heart."

With the stress of dealing with both work and home, Derek and Meredith look to be struggling to keep it together.

Given that smile on Derek's face, we hope that means good news for the patient on Grey's Anatomy.

With so much going on at work and at home, in the operating room is probably the place Derek feels most at ease on Grey's Anatomy.

There it is. There's that Derek Shepherd smile we've all grown to love.

Congrats to Cristina! She's been nominated for a Harper Avery!

The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.

Whatever's going on, Derek looks very serious on Grey's Anatomy.

When someone falls to the floor, Derek and Owen fight to save a life in "Do You Know?"

It's like Derek is smiling into our soul in this Grey's Anatomy image, isn't it?