Given That Smile

Given That Smile

Given that smile on Derek's face, we hope that means good news for the patient on Grey's Anatomy.
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Feeling Overwhelmed

Feeling Overwhelmed

With so much going on at work and at home, in the operating room is probably the place Derek feels most at ease on Grey's Anatomy.
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Derek Smirks

Derek Smirks

There it is. There's that Derek Shepherd smile we've all grown to love.
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Congrats to Cristina

Congrats to Cristina

Congrats to Cristina! She's been nominated for a Harper Avery!
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Meredith & Derek

Meredith & Derek

The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.
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Looking Very Serious

Looking Very Serious

Whatever's going on, Derek looks very serious on Grey's Anatomy.
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Fighting to Save a Life

Fighting to Save a Life

When someone falls to the floor, Derek and Owen fight to save a life in "Do You Know?"
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Smiling Derek

Smiling Derek

It's like Derek is smiling into our soul in this Grey's Anatomy image, isn't it?
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You Can't Please Everyone

You Can't Please Everyone

Unfortunately for McDreamy, Meredith may be the one person who isn't awed by his big news in "Take It Back"
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McDreamy and POTUS

McDreamy and POTUS

Everyone wants Derek, even the President of the United States is giving him a call on Grey's Anatomy.
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Derek Gets An Offer

Derek Gets An Offer

Derek gets an offer that could change everything on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Derek and Baby

Derek and Baby

Derek had to bring the baby in to work on Grey's Anatomy. "Get Up, Stand Up" is the 12th episode of the show's tenth season.
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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Arizona: Oh my God! I mean, I understand why you're into her. She's hot. Wait, she likes you?
Nathan: What? I mean, I'm going to try not to be offended at that.
Arizona: No, no, no. It's just that Derek was--Derek was epic for her. They were the great love story. I mean, that girl's heart beat for Derek Shepherd. It just...it never occurred to me that she would ever be with anyone else. He was perfect. He was everything. That man turned her world. It...I spooked you. Don't be spooked.