George and Izzie will always be close, even though their relationship has been through its ups and downs. What a wonderfully-written scene this was, when he helped her down the aisle.

Alex reacts as Izzie slips away from him, possibly for the last time.

Alex and Izzie in the January 21, 2010 episode of Grey's Anatomy. Will she stick around long after she learns what he did?

Izzie Stevens recovers in her hospital bed and receives an unexpected surprise - her mom!

A photo from the fourth season finale of Grey's Anatomy, "Freedom." Alex Karev tends to Rebecca as Izzie Stevens looks on. What will happen between the two?

The loss is too much for Izzie to bear.

Izzie and Alex embrace in the fifth season finale.

The interns enjoy a lighter moment.

Alex sweeps Izzie off his feet by reciting the wedding vows he made up after being inspired by a patient's planned valedictory speech. Truly touching.

Izzie is caught up in a whirlwind of emotions -- and it won't be the last time.

Is she serious? Well, maybe not. But Izzie Stevens (Emmy winner Katherine Heigl) sure is back in full force and looking forward to running the surgical show in Season Four of Grey's Anatomy.

A trio of interns kicks it.