Izzie Stevens wigs out on Grey's Anatomy. Literally. She's got a wig on.

Drs. Alex Karev and Izzie Stevens, who are married, in Season 6 of Grey's Anatomy. These two make a cute couple, we've always thought - but can their marriage last?

Izzie Stevens (Katherine Heigl) dons a strawberry blonde wig in "I Always Feel Like Somebody's Watchin' Me," from the sixth season of Grey's Anatomy. Are you a fan of the color change?

The surviving four of our five original interns-turned-residents at Seattle Grace. They look to be having some fun here!

We have no idea what's going on here yet, as this episode hasn't aired at the time we're uploading this picture. But it looks funny!

Izzie and Richard in a scene from "Invasion." Could it be that our girl is getting the axe, or at least is placed on temporary leave?

It looks like a tense moment between Izzie and Richard in this scene from "Invasion." Could it be that our fave is getting fired, or at least is placed on temporary leave or suspension?

In this scene from "Invasion," it appears Izzie wants a piece of some of the new residents. Oh, it's going to get ugly this week, alright.

Izzie and Alex got married in May of 2009 near the end of Season 5 of Grey's Anatomy. But life has not gotten any easier since.

Those two new chicks are coming over from Mercy West and totally angling for Izzie's job ... or whatever jobs they can secure. "Invasion" is a good title for this episode.

Do not mess with Izzie Stevens. Cancer, schmancer. Peach Fuzz will mess you up!

What happens on this all-new episode of Grey's Anatomy January 21? You be the judget of that.