Derek Shepherd looks on with those amazing eyes in the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me." But will McDreamy by okay in this episode?

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," and in every episode of Grey's Anatomy, Izzie is unmistakable. She's the best ... but also always close to trouble.

Meredith helps out with patients as the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," is in full, emotional swing.

Dr. Cristina Yang in a still photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me." Will this episode bring her a new love interest?

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Derek Shepherd looks as handsome as ever. But will he be involved in the major car wreck shown at the beginning?

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," guest stars Bernadette Peters and Kathy Baker share the same expressions of concern. Will they be alright?

She's our girl. In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," a lot of people will be wondering if this is the last season for Izzie Stevens (Katherine Heigl).

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Stevens is seen with some of Seattle Grace's newest patients.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Bernadette Peters is one of the primary guest stars. Looking forward to seeing what she brings to Seattle Grace!

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," a couple of new and interesting patients are admitted to Seattle Grace.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Kathy Baker guest stars as one of the patients admitted to Seattle Grace after this episode's major trauma.

In the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," a crisis brings a couple of interesting patients to Seattle Grace.