Katherine makes waves quite often with her outspoken nature, but here, the actress is just waving. Heigl and her co-stars came back in a big way for Season 4 Thursday night!

You knew we weren't going to pass that one up. Izzie does some research in order to save the life of a deer friend. Boy, this is just too easy.

Miranda Bailey is in charge, even if her title doesn't say she's Chief Resident. Alex Karev knows it too.

Meredith Grey has interns of her own now... one of whom is a very familiar face. There's another one who's her sister, who is under Cristina. The world of troubles continues!

Unfortunately, for him, Alex Karev that is, Callie Torres is calling the shots. You would never have guessed it but he finds himself missing Dr. Bailey.

Alex and Callie talk to their patient, unaware that he is about to eat everything in sight. But what are you gonna do.

Three of our favorite Grey's Anatomy stars from day one - Justin Chambers, Katherine Heigl and T.R. Knight. These three and the rest of the cast return for Season Four September 27!

Cinematic Orchestra will have a song featured on the Grey's Anatomy season premiere, "A Change is Gonna Come," in September of 2007. Should be great!

A bad play on words, yes. But T.R. Knight has earned his honor as one of the best male actors on TV, a fact reflected by his recent Emmy Award nomination. We're looking forward to seeing his return to Grey's Anatomy tonight!

Ellen Pompeo with Grey's Anatomy creator and executive producer Shonda Rhimes. Here's hoping they can bring back the magic in this 4th season.

Patrick Dempsey and Ellen Pompeo share an embrace on the set of Grey's Anatomy. More than ever, says Patrick, it's his priority to keep a positive energy on the set of the show.

George and Callie kiss. Are these two going to be back on a normal playing field with Izzie out of the romantic picture?