We're drinking tequila out of sunscreen bottles.

Dee

I'm sorry. Is no one gonna talk about Dee's hair?

Mac

You can't ruin a friendship with sex that's like trying to ruin ice cream with chocolate sprinkles.

Raj

Matt: I don't know why I let you talk me into this.
Jeremy: It's because she's your sister. And you have a chance to help her.

Buck up, sissy pants.

Leonard's mother

You can't blame yourself. When your prefrontal cortex fails to make you happy promiscuity rewards you with the needed flood of dopamine. We, neurobiologists, refer to this as the skank reflex.

Amy

You build your army so big that no one will dare pick a fight.

Klaus

She's a vampire, Carol. We do what we have to do.

Bill

I feel like two totally different people. Dr. Jekyyl and Mrs. Whore.

Penny

Elena: You're the one who told me I can handle things on my own now.
Alaric: I meant like frozen dinners and SATs.

Klaus: Please, forgive the inclusion. My name is Klaus.
Werewolf: You're the hybrid.
Klaus: You've heard of me. Fantastic.

He would never give up on me. I'm not gonna give up on hime.

Elena [on Stefan]