Mark Sloan never loses it in the ER. Not ever.

Addison

Turns out your stupid Post-It is 10 times the marriage my church wedding ever got to be. I'm moving on.

Alex

[to Mer] You gonna look me in the eye and tell me Derek never threw a cranionomy after the two of you spent an hour in the on-call room? Please.

Alex

I'm in the middle of a divorce. People call me the Nazi, and it's not because of my ice blue eyes. I spend 12 hours a day carving people up, and I like it. I have a child and I have no room for casual anything. I'm angry all the time. ... You want lunch, or you wanna show me the scan?

Bailey

[to Alex] Let me scrub in and I'll take you out to drinks afterwards and, you know...

Reed

Addison: You told her?
Mark: She's my kid. We were bonding.
Addison: That's now how you bond with children.
Mark: I'm still getting the hang of it.

[to Der] You wouldn't be starting a conversation about my personal life, would you? Bad idea? Bad idea!

Bailey

Addison: Let me say it once: Grandpa... Grandpa, grandpa, grandpa!
Mark: Okay. That was four times. Get it out of your system?

Get me Addison Montgomery!

Mark

Ask any physician and they can point to the one moment they became a surgeon.

Meredith

I'm a surgeon and I'm looking at a time bomb in a uterus. Shut it down now, Addison!

Mark

Mark: It's the guilt, you know? It's like every time I look at her... I just... The guilt is like a punch in the gut. Everyday.
Derek: Well, you shouldn't feel guilty, you didn't know.
Mark: I did know. I knew it when her mom got pregnant. She told me. I gave her a couple hundred bucks and I left town and I never saw her again. I figured she got an abortion. Hoped. But I did know.
Derek: Well you're a different guy now. You're not 18 anymore, you've grown up, and you're capable of better.

Grey's Anatomy Season 6 Quotes

Sean, I am talking about where I am going to die - you have to be feeling something.

Patient

Arizona: Oh, I have wine. White and Red, and I have cigarettes. Which is awful I know, but I only smoke on very rare, very occasionally. And, only when I know I'm gonna be in trouble. Like now.
Callie: It was inappropriate. Not to mention manipulative and stupid. You smoke?
Arizona: I know. Listen, I know you have every right to be mad at me but I ran out of options. So...
Callie: It's an expensive test, there was no indication to do it, there was a reason Webber turned you down.
Arizona: So you didn't do it?
Callie: Of course I did it Arizona.
Arizona: Thank you!