We know he cheated on you. That's why we let you turn the house...
MEREDITH: "We know he cheated on you. That's why we let you turn the house into Santa's Freaking Village. We're not big on holidays. We're trying to be supportive, because you're having a hard time. But right now, Alex is having a harder time."
IZZIE: "Why should anybody care what kind of time Alex is having!?"
MEREDITH: "Because he's Dirty Uncle Sal!"
IZZIE: [looks confused]
MEREDITH: "Dirty Uncle Sal. The one who embarrasses everyone at holidays and family reunions and who can't be left alone with the teenage girls, but you have to invite him anyway. Look... I have a mother who doesn't recognize me and as far as family goes, you guys are it. So I know you're pissed at Alex, but maybe... maybe you could try and help him anyway. Like, in the spirit of this holiday you keep shoving down everybody's throats."