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After an open house night at the University with grad students, an obsessive student Ramona Nowitzki (Riki Lindhome) likes Sheldon and makes her way into becoming his girlfriend / assistant.  Although Romana starts off being a good influence in high life, she soon begins to cut into his social life (nomore Halo, paintball, comic books, etc).  Ramona even soon gets jealous of Penny.

When Sheldon realizes he's dating Romana, he tries to get Leonard to help him get rid of her.  The final straw comes when after Sheldon solves his scientific problem, she wants credit for helping him work on it by calling it the "Cooper-Nowitzki Theorem."  He immediately kicks her out and tell her to "get out!"

The episode ends with another young woman that approached Sheldon in the same way Romana did and the cycle begins again.

The Big Bang Theory
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The Big Bang Theory Season 2 Episode 6 Quotes

Rajesh: Isn't there a University policy against dating graduate students?
Leonard: No. If you can talk to them, you can ask them out.
Rajesh: Damn, there's always a catch

Sheldon: Please, please, I don't have a lot of time. Ramona finally dozed off and I need you to help me get rid of her.
Penny: Get rid of her how?
Sheldon: I don't know, but apparently I'm in some kind of relationship, and you seem to be an expert at ending them.
Penny: Excuse me?
Sheldon: I see man after man leaving this apartment, never to return.