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Amy gets sexually aroused when they run into Penny's ex, Zack.  Well actually it takes Sheldon and her studying the symptoms to figure it out.  How does Sheldon deal with his "girlfriend" being horny?  By trying to set her up with Zack.  She goes to talk to him, realizes he's a moron, and gives up.  She tries holding Sheldon's hand as an experiment... and it fails.

Meanwhile, Raj and Wolowitz have a competition to see who would be the superhero and who would be the sidekick.

The Big Bang Theory
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The Big Bang Theory Season 4 Episode 10 Quotes

Wolowitz: He got bit by a radioactive rat.
Raj: Did he get superpowers?
Wolotiz: No, he got five stitches and a tetanus shot.

Penny: He wasn't intellectually stimulating enough.
Bernadette: Couldn't you just fool around with him and then listen to NPR?
Penny: Wouldn't help. Zack couldn't even spell NPR.