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When Sheldon and Amy get into an argument about theoretical physics vs neuroscience, the two break up.  A lonely Sheldon turns to a small army of cats until Leonard brings Sheldon's mom in to fix the situation.  She uses reverse psychology to get the two back together and Sheldon gives away his cats.

The Big Bang Theory
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The Big Bang Theory Season 4 Episode 3 Quotes

Wolowitz: Women, huh? Can't live with 'em; can't successfully refute their hypotheses.
Sheldon: Amen to that.

Leonard: Amy is judgmental, sanctimonious, and frankly just obnoxious
Sheldon: So?
Leonard: So we already have you for all that.