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Sara Ramirez is One Smooth Operator

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Sara Ramirez is One Smooth Operator is slightly mortified.

A bus showcasing her image alongside 10 other Grey's Anatomy cast members on a massive promotional poster has just pulled up on the street outside a cafe.

"Oh my God. That is so weird," she cringes.

After the initial shock wears off, she smiles, pleased with the photo.

"For one of the first times, I'm looking at myself going, 'Yeah, I'm OK with that,'" she told USA Today.

Ramirez, 31, should be pleased. After an eight-episode run last season, she's a Grey's Anatomy regular.

And while the other female doctors on TV's hottest medical drama are busy breaking hearts, Ramirez is mending broken bones... as orthopedic surgeon Callie Torres. Soon after she accepted the role, Ramirez made the most of the twisted ankle and torn ligaments she received on stage playing Lady of the Lake in Broadway's Spamalot.

Her orthopedic surgeon let her observe operations.

"I was watching surgeries where they opened up knees and shoulders, taking pictures with my phone," Ramirez said.

The actress, who hails from Mazatlan, Mexico, is no stranger to blood and guts. She's a fan of TV shows about medical procedures and grew up with an oceanographer father who brought her with him to labs.

"I was always around rows of crazy jars that smelled like weird fermenting things from beneath the sea," she said.

Ramirez's parents divorced when she was eight. Her father moved to Miami, and her mother, a former actress / singer, relocated to San Diego, where she enrolled Ramirez in a school for the performing arts.

Like Callie, who at one point was living in the hospital basement, Ramirez has resided in less than luxurious digs. During her 12 years on and off Broadway, Ramirez had several humbling living experiences in New York.

"I ended up renting a room (from) a really eccentric couple," she said. "Then there was a woman who kept every room piled up with clothes and dirty stuff. I found things missing. But it taught me I can live with less."

For now, she's renting a house in Los Angeles.

"If I was to put my money down on a house, I don't know that I'd have much left. I don't know if this job's going to last. But if the show keeps me around for a little while, I'd like to settle down. I'm kind of in that nesting phase," she said.

Ramirez has a boyfriend but prefers talking about her on-screen romance with self-deprecating softie George O'Malley (T.R. Knight).

In tonight's episode, it's make-or-break time for the couple. But Ramirez says the characters are suited for each other.

"She gives him strength, and he gives her sensitivity."

Sara Ramirez is One Smooth Operator 1

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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hi sara i just wanted to let you know i love you sooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooommmmmmmmmmmmmmmuuuuuuuuuuuuuuuuuuccccccccccccccccccchhhhhhhhhhhhhhhhhhhhhhh!

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Sara es una muchacha muy hermosa una de las mejores actrices que he visto y de un fisico mexicano incrible. En Cuba se ve mucho esta serie de anatomia y es super.

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SARA RAMIREZ IS SO GORGEOUS. SHES SO HOTT!.
AND IF THATS REALLY HE BOYFRIEND IN THE PICTURE I FOUND WOW SHE HAS BAD TASTE IN MEN I KEAN COME ON HE IS SO UGLY AND SHE IS LIKE SMOKIN HOTT. BUT BESIDES THAT SARA RAMIREZ IS SO GORGEOUS I REALLY DO HOPE THAT THEY KEEP HER ON THE SHOW AS LONG AS POSSIBLE.! SHE IS REALLY GREAT FOR GEORGE BUT IZZIE IS SCREWIN EVERYTHING UP FOR THEM. I LOVE SARA RAMIREZ!!!

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Although I'm totally pissed at the writers right now for having Izzie and George end up in bed together...I was glad that I saw Sara on screen a little more. She really deserves a show all her own. Anyway...The George I grew to love wouldn't have talked down about Callie to Izzie, and he wouldn't have gotten mad at her for being rich (uhh...hot and loaded...not to mention humble...where is the problem?) Blond with boobs isn't what makes a woman beautiful in my opinion...and I think George lowered his standards.

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I love Sara, seriously, she is so gifted and talented and not 5 and a half pounds like everyone else. She is so beautiful!

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I love love love Sara! :) She is perfect for the role of Callie and has such good chemistry with TR Knight (George)!

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hola, andaba por aqui y me dio muchisimo gusto el ver que Sara es de Mazatlán, Sinaloa por que yo soy de ahi, muchisimo éxito en la vida y los mejores deseos.
Muchisimas FELCIDADES.!!

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I think Sara Ramirez is such an awesome actress. After seeing her in Spamalot, in which she TOTALLY deserved the Tony, I am so glad she is on Grey's Anatomy. She can play such different roles really well. It's really fun to watch her on Grey's Anatomy.

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I admire Sara as an actress. I noticed her on "You've got Mail" and her small part as the cashier at grocery store made me take notice of her. She has features on her face that are stunning. Her character on Grey's Anatomy is very strong, yet vunerable, which is very appealing, makes her more interesting. You can see how good an actress she is by being able to read her mind. I hope she goes a lot farther in her part on the show and I wish her the best of luck.

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omg.i am such a huge fan of callie on this show. she doesnt care about what people think and she is such a strong person. i pretty much look up to her!! I really hope that george and her get back together soon...idk what is up w/ george but he needs to get over it soon! keep it up sara!
-cherilyn

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith