Below is a Q & A with Michael Ausiello of TV Guide, one of the business' foremost providers of spoilers. Read what he has to say about the affair between George and Izzie, as well as other tidbits from inside the walls of Seattle Grace...

Q: Please tell me that Callie will find out soon about George and Izzie whoring around behind her back?
A: Poor Callie will remain blissfully unaware until around... um, let's go with May 10. The following week, I believe the smelly brown stuff hits the fan.

Q: Is Isaiah Washington leaving Grey's Anatomy?
A: If he is, ABC is doing a really good job of keeping a lid on it. This much I know for sure: At the end of next Thursday's episode, Preston Burke starts to have some serious reservations about marrying Cristina... and you won't believe whom he turns to for advice. (Hint: They had a little bit of a dust-up at the Golden Globes.)

Q: On Grey's Anatomy, will Jane Doe get an actual identity before the end of the season?
A: I hear she's getting an actual hubby in the season finale, so it stands to reason that her identity is part of the package.

Q: It seems that, on Grey's Anatomy, Mark's "failure" to go 60 days without sex must mean, dare I say it, that he's unable to have sex? Am I right?
A: Nope.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.