Sara Ramirez didn't join the cast of Grey's Anatomy until Season Two and was not made a full-time cast member until the start of Season Three.
But Sara Ramirez's character of Dr. Callie Torres - recently promoted to Seattle Grace chief resident - sure is in the thick of things here in Season Four.
In fact, Calliope's turbulent love life has been getting a large part of the attention this season, thanks to a possible split from husband George O'Malley (T.R. Knight), who had an affair with his best friend Izzie Stevens (Katherine Heigl).
"Like all the characters on the show, I think Callie has her flaws, issues, hang-ups. We don't know all the ins-and-outs of why she truly was with George. I think there was a pure love there but I'm sure Callie has other issues behind clinging onto something that just isn't right," Ramirez told the Los Angeles Daily News.
While the role on Grey's Anatomy has made the Mexican-American hottie widely known to television audiences, the New York theater scene has been aware of Sara for some time now. In fact, Ramirez won the 2005 Tony Award for her performance as The Lady of the Lake in "Monty Python's Spamalot."
Sara Ramirez is certain she will return to the stage at some point.
"I consider New York and theater my home base, where I sort of grew up," she said. "I miss it and I hope they'll have me back whether it's a musical - it doesn't have to be on Broadway - or a play. I miss the theater, the whole symbiotic relationship between actor and audience and being on stage. The live factor."