Fans may be split (see our Insider poll) over whether they like or dislike T.R. Knight and Katherine Heigl as lovers on Grey's Anatomy, but the pair of stars who portray Drs. George O'Malley and Izzie Stevens sure are best buds off the set.
Here's a candid photo of Katie Heigl and T.R. Knight at Arclight Theaters in Hollywood Monday night, when the components of "Gizzie" enjoyed many laughs as they stopped to sign autographs for fans and pose for the cameras.