Are Alex-Izzie, George-Callie Reunions in Store?

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Drs. Karev and Stevens heated up Grey's Anatomy in Season 2, but as we know, it didn't work out. Since then, they've become good friends... but is that it?

At the SAG Awards Monday night, Justin Chambers (Alex) weighed in on a possible Alex-Izzie reunion on Grey's Anatomy, while his Grey's co-star, Sara Ramirez (Callie) hints that there still may be hope for Callie and George.

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Married Couple

Would you like to see either or both of these couples back together?

Check out TV Guide reporter Michael Ausiello's SAG video to learn more and to watch his interviews with our favorite stars and others in the TV world.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.


alex and izzie are soulmates and are meant to be together i think that callie and george only worked together when georges dad was dying
i HATED the izzie and george pairing and i think that bailey should get someone
i agree seasons 1&2 were the best


I think that Alex/Izzie should be together but I would have to say no to Callie and George because Callie is too good for him. Izzie/George in my opinion have best friend chemistry just not hot sexy relationship chemistry. They are better off as friends. MerDer are adorable and I love them together. I just really want a season where they are together and happy without any interruptions. I feel like they definitely deserve it. As for Ava, she is crazy. I'm glad she's getting help though. I love Lexie but I'm also sad that Burke is gone because now Christina is left with no one and I miss the fun Christina. I hope Season 5 is amazing!


I don't think the show has gotten that bad. Pretty bad, but not bad enough for me to stop watching. The writer's just think that they need to "spice things up", so to speak. But honestly I just think that ALL of the characters need HEALTHY and somewhat NORMAL relationships. To answer Lisa's question in the last five minutes, Mer is talking to her therapist and says that although the patient didn't get to tell his boyfriend that he loved him before he died, she thought he was being heroic. Her therapist tells her that Meredith is, in essence, that patient. Derek is with Rose and because of that she is "dying alone", and that the reason Derek isn't with her is because she's afraid. Meredith says "Are you calling me a coward?" and the therapist responds "What do you think?". Meredith leaves the room and that is the end of the episode. Alright time for my opinions... LexZie - hmmmm if izzie hadn't slept with George and Rebecca wasn't being such a bitch and LYING TO HIM about being pregnant, than I would say they might have a chance of reuniting EVENTUALLY. But as of right now, ehhhhh I don't think so. O'Callie - Hell to the NO. I love George and everything but Callie was just too good for him, and not just because she's uber rich. She tried too hard and cared too much. They better not get back together grrrr. Gizzie - I'm not really sure why they don't have chemistry anymore? But, Izzie knew what she was doing was wrong and did it anyway, THAT immediately disqualifies this couple in my eyes. They're best as BFF's Alex/Ava/Rebecca - Ok, Seriously? The fact that he couldn't give her a reason to stay back when she asked him to should have been a sign. He was a bigger person for it, I think, but if he really had to hesitate at all, then why is he messing around with her at all. And now she's lying to him about being pregnant???? EW. This whole relationship is based on lies on her part and therefore Alex for once deserves better. Christina - I miss her!!!! She used to be hilarious! Now stupid effing Burke left her for a nothing-ness. I want my Christina yang back=[ Lexie - I see more and more of Meredith in her everytime I see her. I kinda feel bad for her, she tries too hard to make people like her. She needs to relax more, and not let Christina push her around. I actually like Lexie now. Derek/Rose - I HOPE ROSE GETS KILLED OFF THE SHOW! She's probably a great character, but the fact that she took Derek away from Meredith KILLS me. Meredith - Yes, she does need to stop whining, but I wouldn't put all the blame on her. It takes two to make a relationship work and it takes two to make their relationship fail. I get that she's not ready, and I can see why she doesn't trust him completely, but he kissed Rose WHEN THEY WERE SEEING OTHER PEOPLE. He shouldn't have done it period, but the seeing other people thing IS the point. Grr to her for that. And as far as Lexie goes, mer should at least try a little. I get why she doesn't want to try, but lexie is NOT Thatcher. And Mer could really use a sister right about now. Derek - McAsshole. Enough said. First he says "I'll wait for you.", then he says "What if I find someone who's ready to give me what I want from you?" Then he says " I slept with her (Rose) and the whole time I was thinking of Meredith." Like I said, it takes two. He was being an asshole, and even if he doesn't like it, he needs to let Meredith see that she CAN trust him and that she is ready to make that next step. MerDer - okay. Here's the big one. I love this couple, with all my heart. And if the look on his face when he begged Mer to ask him to stay. If his statement about sleeping with Rose. And if her obvious heartbreak doesn't just say it all, then I quit. Yes, they had their fair share of problems, even extremely STUPID UNNECESSARY problems, and now they deserve to be happy. I don't think she should just rush back into his arms after the Rose thing, and he shouldn't expect her to just be ready for marriage now that he's done with Rose. I think these two deserve a REAL relationship. A Fresh start, 100% open-ness, and seriously, NO SEX. Like i said, they need a real relationship. I completely lost my train of thought, so I guess this is where I end my ramble. yay.


I think that izzie and mcsteamy or alex should hook up what do your think


Can someone please tell me what happened in the last 5 minutes in the show 5/8. I saw Mer talking to her therapist and my DVR stopped recording there.


george and izzie togetherr!!
alex siempree engañaba a izziee =S


I think that a huge twist should be good for George. Let him be GAY............. This would explain his problems in his relationships with woman.
He was also an outsider in his own family with his brothers. He is not the tough guy.
He is sensible and a best friend to the woman in his environment. Let him hook up with one of the new male characters in the show.




I dont understand why they would put George and Callie together after what happened between them! They suck together. I actually liked the idea of Izzie/George...and not having chemistry??? what the hell is that about? They slept together before and enjoyed it! They had a hot kiss in the elevator! How does chemistry like that all of a sudden disapear? It didnt make any sense, but fine i made my peace with it...but now they are talking about putting george back with callie?? that will ruin the show! He never loved her thats why he cheated! I mean is George! He doesnt cheat...unlike alex at least he loved Izzie, so getting them back together (Even though i dont like the idea) makes more sense. Here's what i think should happen. (George with Lexie)- They would actually make a cute couple...
(Derek/ Meredith)- For the love of god, either get them married or have them brake up for good already! Meredith needs to stop whining and realize that she has a good man who loves her...she makes her life so many death experiences does she need to have to realize that Derek is the guy for her! Enough already! Stop your whining meredith, u werent this whinny in seasons 1 and 2...i miss those seasons too!!
(Izzie/Alex)- Maybe, but if they are thinking about putting them back together...let it last longer than a doesnt have luck with relationships...she gets together with alex in season 2 for about a week, then he cheats on her..she gets engaged and her fiance dies! she finally gets George and they have no chemistry? What the hell...Give Izzie a brake......Lets give her a relationship that has a chance on working..I love Katherine Heigl....
Mark/christina....hhhmmmmmm interesting..but no i dont see it happening ever....I dont know Christina needs a storyline...ever since burg left she is like a floater...she is not even funny anymore...
I dont know the show really went down hill ever since season 2.....


I think that George and Merideth should actually be a couple. Izzie and Alex shouldn't happen, and George and Callie definetly shouldn't happen.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.