Are Alex-Izzie, George-Callie Reunions in Store?

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Drs. Karev and Stevens heated up Grey's Anatomy in Season 2, but as we know, it didn't work out. Since then, they've become good friends... but is that it?

At the SAG Awards Monday night, Justin Chambers (Alex) weighed in on a possible Alex-Izzie reunion on Grey's Anatomy, while his Grey's co-star, Sara Ramirez (Callie) hints that there still may be hope for Callie and George.

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Would you like to see either or both of these couples back together?

Check out TV Guide reporter Michael Ausiello's SAG video to learn more and to watch his interviews with our favorite stars and others in the TV world.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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i agree... season 2 was amazing.. the show really misses burke and addison u can really tell... season 2 was so good cause burke and cristina werent like really really a real couple yet.. the whole merder addison triangle... alex izzie and denny.. and george was just george and i liked it better when they were all interns together cause now the 5 of them are never all together and thats what i liked most about the show
o and baileys becoming too soft

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if bailey doesnt have an affair i am going to quit watching.

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i want to see lexie and george. meredith with a paramedic that has been injured. hahn with mc steamy. callie has a nervous breakdown because of george and went to tend bar at there hangout. izzy and mcdreamy. yang can stay in operating room. chief gives bailey a promotion which makes them together all the time and they have a torrid affair.

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does anyone else remember, s.3ep.6, derek has left mer ("she's always living him"?really?) and doesnt react to her breakup with fin. what does mer do? makes things easier 4 him, by proposing herself to him TO TAKE SOME TIME. she is ok with that. so, whatever

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i agree. all the characters have been destroyed. does anyone recognise these characters;
1. a woman who commits adultery, chases like crazy her married friend and then decides there's no chemistry -not izzie
2. a man who cheats, deceives, lies, breaks up his marriage, only to end his affair due to bad timing??com'on! we could forgive him if all this was about his love of his life, but just give up..?
3. a dreamy man who makes out with a random woman, forgets to mention that to the woman he calls the love of his life and proposed to a few days ago, and then asks this random woman out minutes after his itentional breakup with the woman"for whom he'll always come back for"
5. the main character who btw has undergone 2 near death experiences in like a year, who cannot make up her mind and stop whinning
6. 2 man-whores (alex and mark) who dont seem to grow up -btw i still expect an explanation about mark hitting on mer twice-isnt he suppose to be in SGH 4 derk?
7. 2 characters who just disappeared (callie/christina)

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I agree! I mean, seriously, McDreamy is being a jerk! Someone who asks some nurse out minutes after breaking up with "the love of his life" does not deserve the title "McDreamy".
I don't know about Callie and George, but Izzie and Alex should definitley be together!!!
and I also have to agree about the writing- our favorite show has been in a slump- hopefully the writers' time away from work will due them some good.

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I TOTALLY agree with dalia. I always watch seasons one and two. There AMAZING. Everything is so depressing now. and nothing is funny anymore its just all sad. I miss mcdreammy soo much. Hes not so mcdreamy anymore. I miss it

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i so totally agree! anyone who doupts that the writting has been screwed up (including the writers) should just watch 1 random episode from season 1 or 2 and then the episode that they consinder the best from season 3 or 4 and they'll see what we r talking about! its almost like a different show. god i miss so much the 1st year interns, the friendship between george and izzie (so funny), the strong meredith, christina having storylines, derek being dreamy...

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Yeah I agree, they messed around and now they are all screwed up!!! lol i thought the story was more believable in the first few seasons too, like I'd watch it and think omg that's me or that's my friend ya know, now it's like yeah umm boring or predictable?? idk

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I don't know about you guys, but I wish things would go back to the way they were in seasons 1-mid season 2 :-(

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Grey's Anatomy Quotes

Amelia: I think I'm falling in love with Owen Hunt, and I'm really afraid that it's gonna destroy me.
Derek: It wouldn't be love if it didn't.

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith