Patrick Dempsey's Keys to Relationship Success

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The man known as Dr. McDreamy may not know how to make a marriage last on Grey's Anatomy â€" but the man known as Patrick Dempsey sure does!

"Love, humor, communication. To me those are the bedrocks of a good relationship," the Versace-clad Dempsey, 42, said Monday at the New York City premiere of his wedding-themed romantic comedy, Made of Honor.

Dempsey at the Premiere

The Grey's Anatomy star plays a compulsive womanizer in the comedy, but says the Made of Honor character's "nothing like me at all â€" I'm married and have kids!"

Of his wife, Jillian Dempsey, the appreciative father-of-three said:

"She's immensely supportive. Without her, I wouldn't be here."

They have a six-year-old daughter and one-year-old twin sons.

So does Patrick Dempsey â€" who was recently featured in USA Today among other publications â€" have any funny memories from their 1999 nuptials?

"The photographers were drunk and never got a good picture!" he joked.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Lmao.! The hair! That's not what it used to be...

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Oh man this picture. He looooooooookkkkksss Sooooooooo GOOOD! :)

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How many interviews is he doing??? It is his new full-time job??? And he's always saying the same things: "i love my wife" (that begin to seem fake to me at this point) and "please see my movie". I am getting tired.

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Grey's Anatomy Quotes

Amelia: I think I'm falling in love with Owen Hunt, and I'm really afraid that it's gonna destroy me.
Derek: It wouldn't be love if it didn't.

I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old, in your arms. I don't want 48 uninterrupted hours. I want a lifetime. Mmm. Do you see what happens? I say things like that and you fight the urge to run in the opposite direction. It's okay, I understand. I didn't, but now I do, I do. You're just getting started and I've been doing this for a long time now. Deep down, you're still an intern, and you're not ready.

Derek