Patrick Dempsey's Keys to Relationship Success

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The man known as Dr. McDreamy may not know how to make a marriage last on Grey's Anatomy â€" but the man known as Patrick Dempsey sure does!

"Love, humor, communication. To me those are the bedrocks of a good relationship," the Versace-clad Dempsey, 42, said Monday at the New York City premiere of his wedding-themed romantic comedy, Made of Honor.

Dempsey at the Premiere

The Grey's Anatomy star plays a compulsive womanizer in the comedy, but says the Made of Honor character's "nothing like me at all â€" I'm married and have kids!"

Of his wife, Jillian Dempsey, the appreciative father-of-three said:

"She's immensely supportive. Without her, I wouldn't be here."

They have a six-year-old daughter and one-year-old twin sons.

So does Patrick Dempsey â€" who was recently featured in USA Today among other publications â€" have any funny memories from their 1999 nuptials?

"The photographers were drunk and never got a good picture!" he joked.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Lmao.! The hair! That's not what it used to be...

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Oh man this picture. He looooooooookkkkksss Sooooooooo GOOOD! :)

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How many interviews is he doing??? It is his new full-time job??? And he's always saying the same things: "i love my wife" (that begin to seem fake to me at this point) and "please see my movie". I am getting tired.

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Grey's Anatomy Quotes

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith

Callie: Did anyone ever think you two were a couple?
Meredith: No, because we screw boys like whores on tequila.
Cristina: Then we either try to marry them or drown ourselves.
Callie: Huh.