Patrick Dempsey's Keys to Relationship Success

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The man known as Dr. McDreamy may not know how to make a marriage last on Grey's Anatomy â€" but the man known as Patrick Dempsey sure does!

"Love, humor, communication. To me those are the bedrocks of a good relationship," the Versace-clad Dempsey, 42, said Monday at the New York City premiere of his wedding-themed romantic comedy, Made of Honor.

Dempsey at the Premiere

The Grey's Anatomy star plays a compulsive womanizer in the comedy, but says the Made of Honor character's "nothing like me at all â€" I'm married and have kids!"

Of his wife, Jillian Dempsey, the appreciative father-of-three said:

"She's immensely supportive. Without her, I wouldn't be here."

They have a six-year-old daughter and one-year-old twin sons.

So does Patrick Dempsey â€" who was recently featured in USA Today among other publications â€" have any funny memories from their 1999 nuptials?

"The photographers were drunk and never got a good picture!" he joked.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."