In case you were unaware, Patrick Dempsey is handsome. He's also hilarious! The Grey's Anatomy star (TV's sexiest) exhibits both in the video clip below, from his recent appearance on The Ellen DeGeneres Show. Enjoy!

[youtube]http://www.youtube.com/watch?v=92h5eX7vVDI[/youtube]

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.