Trio of Guest Stars Lined Up For Season 5 Opener

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Dr. Bailey and the gang — but mainly Bailey — will have their hands full in the two-hour Grey's Anatomy Season Five premiere, TV Guide reports.

Why? A trio of gal pals of a certain age descends on Seattle Grace.

In the September 25 episode, Bernadette Peters, Mariette Hartley and Kathy Baker will guest star as friends who each require the hospital's care.

This comes the very same night that Jeffrey Dean Morgan reprises his role of Denny Duquette, although our guess is that is a separate story line.

Free Clinic

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Amelia: I think I'm falling in love with Owen Hunt, and I'm really afraid that it's gonna destroy me.
Derek: It wouldn't be love if it didn't.

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)