Say it ain't so, Masi Oka and James Kyson Lee!

The actors that portray BFF Hiro and Ando on Heroes recently spoke with Kristin from E! Online about the future of their characters' friendship. All might not end well.

"These two characters have always been good, loyal friends, but in this show, you can never try to predict what happens, because once you think you know, you don't," Lee said.

On Heroes, as illustrated in this photo, it appears Hiro wants to leave Ando behind.

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.