Prady said that "When it comes to Leonard and Penny, Wolowitz will explain to Leonard that opportunities to hook up with women appear like launch windows to the moon -- if you miss one, it might be awhile until another one appears. This will become apparent when Penny starts dating a comic-book-loving friend of the guys."
As far as the rest of the gang, "Koothrappali will continue to try to speak to women, Wolowitz will raise his standards (thus lowering his success rate), and Sheldon will inch ever closer to a complete understanding of the universe and everything in it -- except people."
Remember the last launch window you had Leonard? Way to screw it up.