The Big Bang Theory to Collide with Grey's Anatomy

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One of our favorite sitcom stars is set to guest star on one of our favorite dramas.

Exciting casting news today out of Grey's Anatomy, as the show has booked Kaley Cuoco for a role on the May 14 season finale.

Kaley Cuoco, who brings the beauty to The Big Bang Theory every week as Penny, admitted to Entertainment Weekly that she has knows nothing about the character she'll play.

Kaley Cuoco as Penny

"It is a big ol' secret. I have no clue what I am doing," she told columnist Michael Ausiello. "I swear on my life that I have no idea what I am playing because it is the finale and they are keeping it under wraps until the last possible moment."

The actress is also set to guest star on the next two episodes of Gossip Girl. Look for her as the character of Rebecca Dubrovich in "Seder Anything" and "Loose Ends."

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.

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Grey's Anatomy Quotes

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith

Callie: Did anyone ever think you two were a couple?
Meredith: No, because we screw boys like whores on tequila.
Cristina: Then we either try to marry them or drown ourselves.
Callie: Huh.