The Big Bang Theory to Collide with Grey's Anatomy

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One of our favorite sitcom stars is set to guest star on one of our favorite dramas.

Exciting casting news today out of Grey's Anatomy, as the show has booked Kaley Cuoco for a role on the May 14 season finale.

Kaley Cuoco, who brings the beauty to The Big Bang Theory every week as Penny, admitted to Entertainment Weekly that she has knows nothing about the character she'll play.

Kaley Cuoco as Penny

"It is a big ol' secret. I have no clue what I am doing," she told columnist Michael Ausiello. "I swear on my life that I have no idea what I am playing because it is the finale and they are keeping it under wraps until the last possible moment."

The actress is also set to guest star on the next two episodes of Gossip Girl. Look for her as the character of Rebecca Dubrovich in "Seder Anything" and "Loose Ends."

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.

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Grey's Anatomy Quotes

We're all going to die. We don't get much say over how or when, but we do get to decide how we're gonna live. So, do it. Decide. Is this the life you want to live? Is this the person you want to love? Is this the best you can be? Can you be stronger? Kinder? More Compassionate? Decide. Breathe in. Breathe out and decide.

Richard

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)