The Big Bang Theory to Collide with Grey's Anatomy

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One of our favorite sitcom stars is set to guest star on one of our favorite dramas.

Exciting casting news today out of Grey's Anatomy, as the show has booked Kaley Cuoco for a role on the May 14 season finale.

Kaley Cuoco, who brings the beauty to The Big Bang Theory every week as Penny, admitted to Entertainment Weekly that she has knows nothing about the character she'll play.

Kaley Cuoco as Penny

"It is a big ol' secret. I have no clue what I am doing," she told columnist Michael Ausiello. "I swear on my life that I have no idea what I am playing because it is the finale and they are keeping it under wraps until the last possible moment."

The actress is also set to guest star on the next two episodes of Gossip Girl. Look for her as the character of Rebecca Dubrovich in "Seder Anything" and "Loose Ends."

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.

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Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)