Jeffrey Dean Morgan confirms what the sneak previews of "What a Difference a Day Makes" have already shown - that he will reprise his role as Denny on Grey's Anatomy once again in this fifth season. But then that's it, he insists. Really.

"I can confirm that I will be coming back one more time," he revealed to EW at last weekend's Hollywood premiere of Star Trek. "I think it will be done after that. I think that I have officially been on the Grey's Anatomy set for the last time."

Morgan wouldn't comment on when exactly Denny turns up, but we know he will reappear as a figment of Izzie's cancer-ravaged imagination in Thursday's 100th episode.

"Denny has a reason to show up," Morgan teased.

"And it's probably tied to Izzie's health."

Given the number of times Denny has returned to Grey's Anatomy since he died in the epic Season 2 finale three years ago, Morgan states the obvious when he says:

"I think they're regretting killing me off a little bit. But it's done and it's been great. I love those people. Shonda Rhimes gave me the opportunity of a lifetime."

What do you think brings Denny back? Will you be sad to see him go?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.