Tonight, Grey's Anatomy finally returns for its sixth season. It will be a season of change, a season of transition, and a season unlike any we've seen up until now.

Will it be one of our favorite show's better campaigns? We remain hopeful!

One of Seattle Grace's own is laid to rest this evening in the two-hour premiere, divided into a pair of episodes, fittingly entitled "Good Mourning" and "Goodbye."

Everyone will handle the passing of George O'Malley differently, and in their own way, as the stage is set for a number of intriguing stories and plot lines to follow.

We've seen some quality sneak previews and promos for this much-anticipated event, as well as pictures and spoilers galore giving us clues as to what's to come.

Now it's time to sit back, enjoy, and share your predictions and impressions.

What do you think and hope will happen on Grey's Anatomy tonight?

Discuss tonight's season premiere by leaving comments below and chatting with other fans in our

Big changes are coming to Seattle Grace. Just ask The Chief.

As always, our official recap, Grey's Anatomy quotes, music and analysis will be posted ASAP for your enjoyment. Thank you as always for visiting Grey's Anatomy Insider and being a part of the show's #1 fan community! We look forward to watching the premiere with you!

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.