Grey's Anatomy Spoilers: Are Alex and Izzie Done?

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Will Alex and Izzie remain together on Grey's Anatomy?

From previous spoilers (and the impression we get), we feel confident in sticking a fork in Lexie and Mark, at least for the time being. But what about Izzie and Alex?

Katherine Heigl returns to Grey's Anatomy this week in "I Like You So Much Better When You're Naked." But as the sneak peeks show, the reunion is far from joyful.

According to insiders, when it comes to their future, "all bets are off." So basically, no one has any real idea what will happen after Izzie leaves Seattle Grace again.

Izzie is Back

As for Alex's professional life, Arizona may be playing a bigger role. "I finally bring Alex back in the fold," Jessica Capshaw told TV Guide. "Arizona ends up advocating for Alex to find his way in peds and see if he can hack it. He has a very hardcore experience."

The actress who plays Dr. Robbins says she wants to prove working with kids isn't all fluff: "Anyone can operate on brains, but try and operate on baby brains!"

Do you want Alex and Izzie to stay together?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Meredith: You're me.
Amelia: What?
Meredith: You're me before Derek. I can be here for you. I can do this. I get you. I can be a twisted sister for you. Just tell me how do you want to play this?

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)