It looks all but certain at this point, but if there were a nail to be placed in the proverbial coffin of Mark and Lexie on Grey's Anatomy, Eric Dane may have done so last week.

If her second hookup with Alex wasn't proof that the relationship is dead, or at least in a coma, Dane said “We’re done,” when asked about it his Valentine’s Day premiere.

“At least done for now. Mark is stubborn and was shocked and hurt by her and he isn’t going to let that go very easily.” It certainly showed in "Valentine's Day Massacre."

As for Mark’s surprise progeny Sloan, whose arrival indirectly doomed Mexie, the book appears to be closed. “I don’t know if we will see the daughter again," Dane said.

Mark and Lexie had a good run, but it appears over ... for now.

In other Grey's Anatomy news, Sara Gilbert will play a patient in an episode slated to air in March or April. Not the same patient Gilbert played on Private Practice, BT-Dubs.

You'd think if the Grey's Anatomy and Private Practice cast members cross over so often, they could keep their guest stars consistent too, right? No big deal, just asking.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.