Are Mark and Lexie Done on Grey's Anatomy?

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It looks all but certain at this point, but if there were a nail to be placed in the proverbial coffin of Mark and Lexie on Grey's Anatomy, Eric Dane may have done so last week.

If her second hookup with Alex wasn't proof that the relationship is dead, or at least in a coma, Dane said “We’re done,” when asked about it his Valentine’s Day premiere.

“At least done for now. Mark is stubborn and was shocked and hurt by her and he isn’t going to let that go very easily.” It certainly showed in "Valentine's Day Massacre."

As for Mark’s surprise progeny Sloan, whose arrival indirectly doomed Mexie, the book appears to be closed. “I don’t know if we will see the daughter again," Dane said.

Father of Sloane
Lexie. Lexie Grey.

Mark and Lexie had a good run, but it appears over ... for now.

In other Grey's Anatomy news, Sara Gilbert will play a patient in an episode slated to air in March or April. Not the same patient Gilbert played on Private Practice, BT-Dubs.

You'd think if the Grey's Anatomy and Private Practice cast members cross over so often, they could keep their guest stars consistent too, right? No big deal, just asking.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."