Are Mark and Lexie Done on Grey's Anatomy?

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It looks all but certain at this point, but if there were a nail to be placed in the proverbial coffin of Mark and Lexie on Grey's Anatomy, Eric Dane may have done so last week.

If her second hookup with Alex wasn't proof that the relationship is dead, or at least in a coma, Dane said “We’re done,” when asked about it his Valentine’s Day premiere.

“At least done for now. Mark is stubborn and was shocked and hurt by her and he isn’t going to let that go very easily.” It certainly showed in "Valentine's Day Massacre."

As for Mark’s surprise progeny Sloan, whose arrival indirectly doomed Mexie, the book appears to be closed. “I don’t know if we will see the daughter again," Dane said.

Father of Sloane
Lexie. Lexie Grey.

Mark and Lexie had a good run, but it appears over ... for now.

In other Grey's Anatomy news, Sara Gilbert will play a patient in an episode slated to air in March or April. Not the same patient Gilbert played on Private Practice, BT-Dubs.

You'd think if the Grey's Anatomy and Private Practice cast members cross over so often, they could keep their guest stars consistent too, right? No big deal, just asking.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith