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Coming to Grey's Anatomy: New Hookup, Devastating Breakup

by at . Comments

Brace yourself, Grey's Anatomy fans.

According to inside sources, there's a major shakeup coming by the end of this season - one that will result in a Seattle Grace couple calling it quits. But this is heavier than usual.

Apparently, it's "one of the longer-term, most-loved couples" that splits up, and it's "going to leave both of them pretty devastated." Doesn't sound good, does it? There's more still.

The backdrop of the breakup involves "a very serious issue "that it certainly seems like the two cannot get past - and does not arise because either of them have met someone new.

Any guesses?

Gather 'Round

Everybody's going to be glued to Grey's Anatomy message boards after this.

Meanwhile, there's also going to be a new fling in the hospital we love, and it involves one of the newcomers this season, and someone who's been around for a good long while. 

One clue to the hookup: It stinks (and only die-hard fans of a certain other show will get that reference)! If you have any theories on this, we'd welcome them in the comments.

Finally, we hear that the Grey's Anatomy sixth season finale will be "a serious game changer for every single character." Okay, Shonda Rhimes said that, but it's worth repeating.

Sound off below with who you think the breakup - and hookup - involves, and what you think the upcoming season-ending Grey's Anatomy bonanza will entail ...

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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I think that the break up will be between Christina and Mer. Christina has become VERY emotionaaly invested with Owen, somwthing she really never was with Burke. She REALLy loves him. When Mer tries to break them up he and Christina will feel the reprecusions becuase Christina never tried to break Derek and Mer up. This would be a huge jaw dropper from the writier. AS for the two getting together.... Well we already know that it involves Mark. Maybe Mark and Callie decide to get together to have a baby. Or maybe the realtionship she is refering to is one with Mark and his grandson. I bet he and Callie adopt the baby!!!

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I think it's Izzie/Alex. You can't just end it with "she sent the papers." I mean, COME ON, he went through her cancer battle with her. Merder= no. C/O= No, he said he loved her and even took her to see his mom. Lexie and Mark SERIOUSLY need to get back together. C/A: I love them together. Why can't it be a happy SF? That would be a shocker. Ha. And happy endings can make people cry too.

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Oh, by the way, it won't work, because this show is focused on incotrolable feelings and urges and passion. So, on S7 Callie will be pregnant but still in love with Arizona, while Arizona will gradually come to terms with motherhood (sincne she won't be the one going through the hard part) and the two girls will end up back together, wich will raise issues for Marc, since he will be left out. This thing will end up in court (I'm a laywer, I've seen this happen).

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I' no expert, but my guesses are: Callie wants a baby, Arizona doesn't. So, they're the ones breaking up. On the other hand, Mark wants a family now more than ever, his relationship with his daughter might improve, but he's missed out too much. The fling with Teddy isn't enough. AND he has just held his grandchild in his arms only to lose her 5 minutes later. So, the baby-craving, and friends for a long time (not to mention compatible lovers) will do each other a favor and hook up, in order to produce the baby that will complete their lives.

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I think the BIG breakup is going to be either btwn Christina and Owen and She will hook up with Jackson OR it will be btwn Callie and Arizona and Callie witll be with Mark Sloan.. I guess we'll wait and see to find out.....

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I LOOOOOOOOOOOOOOOOOVE CalZone.
if they break up i'll probably curl into a ball and die. Heigl's leaving, so its probably Izzie & Alex (but havn't they been kinda broken for a while now?)
Guess I'll have to wait and see....

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IT'S IZZIE AND ALEX!

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PLEASE DON'T BREAK UP CALLIE AND ARIZONA!! it's the only reason I watch Grey's! I'll be heartbroken! Callie's finally happy and Arizona is amazing, they can't do this! It just makes the whole thing worthless! please be Owen and Christina

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its been cleared that the hookup involves Mark..now the other person is a newcomer..and its not Teddy..this leaves us with April (no coz of the derek thing), reed (no coz she's leaving next season), avery and percy (i doubt he would be turning gay like callie)..and HIS DAUGHTER!! just sayin...it stinks remember?;)

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Maybe the break up is Meredith and Christina. They have been the most loved, longest "couple" in the show.

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith