Grey's Anatomy Scoop: Lexie and Mark to Reunite After All?

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With Grey's Anatomy building toward its game-changing Season Six conclusion, many things remain up in the air, among them a big hookup and breakup to come.

Regarding the hookup, we know Mark Sloan is involved, but instead of spelling doom for a reconciliation with Lexie, might this be the catalyst for such a thing?

Perhaps there's hope yet for fans of the former (and future?) pair. Here are excerpts from E!'s spoiler Q&A today about that and other Grey's Anatomy topics ...

Sensitivity training: And taking a note from the The Office, Seattle Grace is about to enroll in sensitivity training after making light of a 700-pound (really) patient they must work on. Thank goodness Michael Scott doesn't work in the medical profession.

Sloan Pic
Younger Grey

The downside of Chiefdom: Life's going to get a little less peachy for Chief Derek Shepherd when he's forced to respond to a wrongful death suit against him.

Who hooks up: As for the upcoming hookup, we already know McSteamy's on the prowl, and let's just say that Lexie is going to have some serious issues with this. The good thing is that it's clear Lexie still has feelings for Sloan.

It's far from certain, but them getting back together is something to bet on.

Who breaks up: It's pretty clear from recent comments by Patrick Dempsey that it's not Meredith and Derek breaking up. An interview with Kevin McKidd to be released next week should make it pretty obvious as to whether Cristina and Owen call it quits.

Hmm. Who do you think breaks up on Grey's Anatomy?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.