With Grey's Anatomy building toward its game-changing Season Six conclusion, many things remain up in the air, among them a big hookup and breakup to come.

Regarding the hookup, we know Mark Sloan is involved, but instead of spelling doom for a reconciliation with Lexie, might this be the catalyst for such a thing?

Perhaps there's hope yet for fans of the former (and future?) pair. Here are excerpts from E!'s spoiler Q&A today about that and other Grey's Anatomy topics ...

Sensitivity training: And taking a note from the The Office, Seattle Grace is about to enroll in sensitivity training after making light of a 700-pound (really) patient they must work on. Thank goodness Michael Scott doesn't work in the medical profession.

The downside of Chiefdom: Life's going to get a little less peachy for Chief Derek Shepherd when he's forced to respond to a wrongful death suit against him.

Who hooks up: As for the upcoming hookup, we already know McSteamy's on the prowl, and let's just say that Lexie is going to have some serious issues with this. The good thing is that it's clear Lexie still has feelings for Sloan.

It's far from certain, but them getting back together is something to bet on.

Who breaks up: It's pretty clear from recent comments by Patrick Dempsey that it's not Meredith and Derek breaking up. An interview with Kevin McKidd to be released next week should make it pretty obvious as to whether Cristina and Owen call it quits.

Hmm. Who do you think breaks up on Grey's Anatomy?

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.