Who Will Mark Hook Up With on Grey's Anatomy?

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One of the burning questions as Season Six of Grey's Anatomy winds down is who Mark Sloan hooks up with - an incident that may end up driving him back to Lexie.

We know for a fact that Teddy, who McSteamy quasi-dated, is not involved in this scenario. We also know it isn't Bailey or Meredith, because ... well, come on, right?

There are some other long shots out there (Cristina, Arizona), because you just never know, but in all likelihood we see it narrowing down to three primary options:

Callie Torres or one of the two Mercy West transplants.

Callie's relationship with Arizona seems a likely candidate for this May's big breakup, and we know her history with Mark. Reed and April? They're ... well, available.

Who do you think it is? Vote and comment below ...

Father of Sloan

Mark Sloan is totally going to get with ...

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.


Wendell in Miami: Can you tell us who the big breakup and hookup is on Grey's Anatomy?
The breakup is, sadly, the one you're all assuming. The hookup is Sloane and Reed, and Lexie is not going to hide her disapproval from Reed, taking little jabs at her in front of patients. Clearly, Lexie is not over Steamy. Grey's returns this Thursday so you can start seeing it all unfold.


Mer did sleep her way through Europe. But Mer said she had to stop partying when she got back from Europe cos her mom had been diagnosed with Alztheimers. Mer did sleep with several in appropriate guys after breaking up with Der. She foolishly slept with George cos he caught her at a very vunerable moment when she just seen her father for the first time since she was 5 years old. But she didn't sleep with Finn and ended up commiting audltery with Der. But she's happily married Meredith and I can't see her or Der straying


Dark and Twisty I agree with you. That is insulting to AZ to think that she would just be with anyone man or woman. And it also pisses me off when people think that Callie should go back to Mark. She is in a loving relationship with AZ. I'm sorry about the horse face comment. But I don't really care for her or Owen. I can't stand to see him with Cris. Everytime he kisses her it looks scary and abusive.


Who thought it so clever to put Arizona on this poll or to vote for her? When Alex and Izzie broke up did anyone think he would run to another guy's bed? Or that Lexie would go after the next girl she saw to get over Mark? What about the zillion "inappropriate guys" Mer slept with before happy married Mer? Anyone suggesting she would go either way? Not so much.... Sure, this is Grey's and that means drama. But it is also about character reality - Arizona is gay, always has been. It's not a switch that you flip on and off. Insulting to have her considered here - why not put Alex or Big Foot on the list as well?


hey guys don't take this the wrong way or anything but some of the comments are really rude to the actors. It's one thing to voice your opinion thats completely fine but there's no reason to insult the people that make this show enjoyable for you to watch. I'm not saying don't hate the character because characters are there for us to love AND hate but you don't have to take it out on the actor by calling them horseface or something rude like that. Even if you resent their place on the show just be polite.


It is not going to be Callie. Cause Callie and AZ are not going to break up. AZ did and interview and she said there are going to be bumps in the road for the 2 of them and they ALMOST break up and then get back together. SR tweeted that they are MFEO. Made for each other and they are't going any where. And she said she is invested in there relationship. They will have there problems but in the end they will stay together. I don't think SR wants to go through all she went through when Callica ended. So I don't think anything is going to happen to them. I think the break up is going to be Owen and Cris. She needs to get away from him. Before he hurts her. And besides she is affraid of him. If they do break up. I hope she hooks up with Jackson. He is soooo cute. Then Owen can have Horse face. And Sloan needs to go back to Lexie. And Alex need to hook up with Reed. And Keptner can get lost in the parking lot with NoseDive. And no body better mess with MerDer. They are happy shiny people and they don't need any trama or drama. And bring back Dr Bailey's gasman. She is really cute with him. But first hook her up with some condoms. LOL!!! Cause the forth date might be the sex date. LOL!!! Although Callie thought the 3rd date was the sex date. Now we know Callie works fast and goes and has her surgical field waxed. OUCH!!! LOL!!! Let freedom ring. LOL!!!


HAHAHA MARK AND CHRISTINA ?!? dont make me laugh so hard ! never gonna happen


Only Mark and Lexie.Thats it.
Shonda should make sure to fix Sloan's mistake ,its only her fault they broke up.
I want to feel their true love again.


plus Reed's nickname on Heroes was Stinkarella


I think it is April ( to get over her obsession with Derek and plus it would really make Lexie mad) or Reed because well they are both newcomers


Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Burke was- He took something from me. He took little pieces of me, little pieces over time, so small I didn't even notice, you know? He wanted me to be something I wasn't, and I made myself into what he wanted. One day I was me Cristina Yang, and then suddenly I was lying for him, and jeopardizing my career, and agreeing to be married and wearing a ring, and being a bride. Until I was standing there in a wedding dress with no eyebrows, and I wasn't Cristina Yang anymore. And even then, I would've married him. I would have. I lost myself for a long time. And now that I'm finally me again, I can't. I love you. I love you more than I loved Burke. I love you. And that scares the crap out of me because when you asked me to ignore Teddy's page, you took a piece of me, and I let you. And that will never happen again.