A second sneak preview of the eighth season premiere of Grey's Anatomy features Derek in mid-surgery when he gets a troublesome phone call. Things in the OR quickly grow tense.

Desperate for answers - and to find his wife and baby - the normally composed Derek is left reeling, wondering what went wrong and what, if anything, he can do right now.

Meredith, meanwhile, is seen moving hurriedly with Zola, wondering what she has done ...

As we saw in the first sneak peek from "Free Fallin'," Meredith has been cut loose from Seattle Grace, at least for now. Might she be reacting hastily to that upsetting news?

Comments and theories on the September 22 Grey's Anatomy premiere are welcomed.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.