Grey's Anatomy Season Premiere Sneak Peek: What Have I Done?

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A second sneak preview of the eighth season premiere of Grey's Anatomy features Derek in mid-surgery when he gets a troublesome phone call. Things in the OR quickly grow tense.

Desperate for answers - and to find his wife and baby - the normally composed Derek is left reeling, wondering what went wrong and what, if anything, he can do right now.

Meredith, meanwhile, is seen moving hurriedly with Zola, wondering what she has done ...

As we saw in the first sneak peek from "Free Fallin'," Meredith has been cut loose from Seattle Grace, at least for now. Might she be reacting hastily to that upsetting news?

Comments and theories on the September 22 Grey's Anatomy premiere are welcomed.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

There's a reason I said I'd be happy alone. It wasn't 'cause I thought I'd be happy alone. It was because I thought if I loved someone and then it fell apart, I might not make it. It's easier to be alone, because what if you learn that you need love and you don't have it? What if you like it and lean on it? What if you shape your life around it and then it falls apart? Can you even survive that kind of pain? Losing love is like organ damage. It's like dying. The only difference is death ends. This? It could go on forever.

Meredith

You think that true love is the only thing that can crush your heart; that will take your life and light it up or destroy it. Then you become a mother.

Meredith