Grey's Anatomy Season Premiere Sneak Peek: What Have I Done?

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A second sneak preview of the eighth season premiere of Grey's Anatomy features Derek in mid-surgery when he gets a troublesome phone call. Things in the OR quickly grow tense.

Desperate for answers - and to find his wife and baby - the normally composed Derek is left reeling, wondering what went wrong and what, if anything, he can do right now.

Meredith, meanwhile, is seen moving hurriedly with Zola, wondering what she has done ...

As we saw in the first sneak peek from "Free Fallin'," Meredith has been cut loose from Seattle Grace, at least for now. Might she be reacting hastily to that upsetting news?

Comments and theories on the September 22 Grey's Anatomy premiere are welcomed.

Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.

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Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

MEREDITH: "You don't get to call me a whore. When I met you, I thought I had found the person that I was going to spend the rest of my life with. I was done! All the boys and all the bars and all the obvious daddy issues, who cares? I was done. You left me. You chose Addison. I'm all glued back together now. I make no apologies for how I chose to repair what you broke. You don't get to call me a whore."
DEREK: "This thing with us is finished. It's over."
MEREDITH: "Finally."
DEREK: "Yeah, it's done."
MEREDITH: "It is done."