April Kepner was introduced in the episode "Invasion" as a former surgical resident at Mercy West Hospital who joins the staff at Seattle Grace Mercy West after the two hospitals merge.

Much of her background is revealed in the episode "Death and All His Friends." While being held at gunpoint by Gary Clark, she tells him about her life in an attempt to convince him not to shoot her, a technique she says she learned from watching Oprah. She was born on April 23 and grew up in Columbus, Ohio. Her mother Karen is a teacher, and her father Joe is a corn farmer. She is the second of four daughters; her sisters are Libby, Kimmie, and Alice.

Following the shooting, April and Jackson Avery move in with Meredith, who also lives with Derek, Lexie, and Alex Karev. April and Meredith become closer in season seven, prompting a jealous outburst from Meredith's sister Lexie. April reveals that she is a virgin because she wants the first time she has sex to be special. The other surgical residents make fun of her, but she advises them not to judge her, as she does not judge them.

April Kepner Quotes

It's weird, it's weird, it's weird. I mean he's old and mean. He's like the Grinch.

April

Callie: Kepner, I need you to speak differently.
April: I'm sorry.
Callie: It's your voice. It's a little um—just speak differently.
April: Like with an accent?

Grey's Anatomy Quotes

[narrating] "At some point, you have to make a decision. Boundaries don't keep other people out, they fence you in. Life is messy, that's how we're made. So you can waste your life drawing lines or you can live your life crossing them. But there are some lines that are way too dangerous to cross. Here's what I know. If you're willing to throw caution to the wind and take a chance, the view from the other side... is spectacular."

MEREDITH

[narrating] The human life is made up of choices. Yes or no. In or out. Up or down. And then there are the choices that matter. Love or hate. To be a hero or to be a coward. To fight or to give in. To live. Or die. Live or die. That's the important choice. And it's not always in our hands.

Derek