April Kepner was introduced in the episode "Invasion" as a former surgical resident at Mercy West Hospital who joins the staff at Seattle Grace Mercy West after the two hospitals merge.

Much of her background is revealed in the episode "Death and All His Friends." While being held at gunpoint by Gary Clark, she tells him about her life in an attempt to convince him not to shoot her, a technique she says she learned from watching Oprah. She was born on April 23 and grew up in Columbus, Ohio. Her mother Karen is a teacher, and her father Joe is a corn farmer. She is the second of four daughters; her sisters are Libby, Kimmie, and Alice.

Following the shooting, April and Jackson Avery move in with Meredith, who also lives with Derek, Lexie, and Alex Karev. April and Meredith become closer in season seven, prompting a jealous outburst from Meredith's sister Lexie. April reveals that she is a virgin because she wants the first time she has sex to be special. The other surgical residents make fun of her, but she advises them not to judge her, as she does not judge them.

April Kepner Quotes

It's weird, it's weird, it's weird. I mean he's old and mean. He's like the Grinch.

April

Callie: Kepner, I need you to speak differently.
April: I'm sorry.
Callie: It's your voice. It's a little um—just speak differently.
April: Like with an accent?

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

When we say things like "people don't change" it drives scientist crazy because change is literally the only constant in all of science. Energy. Matter. It's always changing, morphing, merging, growing, dying. It's the way people try not to change that's unnatural. The way we cling to what things were instead of letting things be what they are. The way we cling to old memories instead of forming new ones. The way we insist on believing despite every scientific indication that anything in this lifetime is permanent. Change is constant. How we experience change that's up to us. It can feel like death or it can feel like a second chance at life. If we open our fingers, loosen our grips, go with it, it can feel like pure adrenaline. Like at any moment we can have another chance at life. Like at any moment, we can be born all over again.

Meredith