Introduced near the end of Season Two as the love interest of George - and now his wife - this orthopedic surgeon is not afraid to ruffle the interns' feathers.

Dr. Calliope "Callie" Torres first appeared in episode the "What Have I Done to Deserve This?" She met George when treating him for a dislocated shoulder, which he suffered falling down the stairs... fleeing Meredith.

While she appears to be a strong woman on the surface, Calliope clearly has her insecurities. She grew defensive after being criticized by Izzie for not washing her hands after using the bathroom, and actually lives in the hospital basement, as discerned by George in "The Name of The Game."

Yet she clearly adores Dr. O'Malley, which dawned on Izzie eventually, as the blonde beauty famously noted, "Oh my god... George is her McDreamy!"

In the episode "17 Seconds," Callie proclaims her love for George, later revealing that this was the first time she said that to a man. While he didn't say it back, he admitted that he wanted to give himself the chance to. Callie replied that she "hates that she's so into" George.

But she is, just the same. Despite breaking up with O'Malley early in Season Three and having a brief fling with Mark Sloan, she realized she wants to be with George and married him in Las Vegas - possibly in haste after his father had just died. She is not aware he soon had a drunken affair with Izzie, although Callie sure has her suspicions and is determined to keep her man.

Callie Torres Quotes

Callie: Did anyone ever think you two were a couple?
Meredith: No, because we screw boys like whores on tequila.
Cristina: Then we either try to marry them or drown ourselves.
Callie: Huh.

We’ve all done things we weren’t proud of. I understand that. I know nobody’s perfect, but how do you live with it? How do you get up every morning knowing you could have done better, that you should have done better? Is being sorry enough? Can an apology actually heal our wounds? Ease our pain? Can it undo the hurt that we’ve caused?

Callie

Grey's Anatomy Quotes

[narrating] "At some point, you have to make a decision. Boundaries don't keep other people out, they fence you in. Life is messy, that's how we're made. So you can waste your life drawing lines or you can live your life crossing them. But there are some lines that are way too dangerous to cross. Here's what I know. If you're willing to throw caution to the wind and take a chance, the view from the other side... is spectacular."

MEREDITH

[narrating] The human life is made up of choices. Yes or no. In or out. Up or down. And then there are the choices that matter. Love or hate. To be a hero or to be a coward. To fight or to give in. To live. Or die. Live or die. That's the important choice. And it's not always in our hands.

Derek