When we first got to know Dr. O'Malley, he harbored a secret crush on Meredith, with whom he shares a house, from day one. George also has a host of other insecurities. His positive outlook on life, and the fact that he is more emotional than most men, often lead to conflict with other doctors.

George doesn't fit in with his own family, either. A Thanksgiving hunting trip resulted in a George unloading a lot of emotional baggage during a conversation with his blue-collar dad and brothers (one of whom later shot the dad, forcing George to operate).

A friend and confidant of Izzie, George won praise among the entire hospital staff for saving a man's life in an elevator during a power failure. With Dr. Burke talking him through it, George stopped the bleeding in a patient's heart single-handedly after Alex choked under pressure.

After great inner strife, he admitted his feelings for Meredith and slept with her in a moment of peak vulnerability for both. After some disastrous fallout, he moved out of her house and onto Dr. Burke's sofa. He remained there until Season Two came to a close - and he found a spot in bed next to his girlfriend, Callie Torres.

In the hospital basement.

Season Three was a tough one on George O'Malley. His father had a heart surgery, then succumbed to cancer. He and Callie broke up, then married in an impromptu Las Vegas ceremony. Then he drunkenly slept with his best friend, Izzie, and has doubted his future with Callie ever since. No one knows where the carousel that is George's personal life will stop, but one thing is for sure - it's a bumpy ride.

George O'Malley Quotes

IZZIE: "You want us to make her seize? How do we make someone have a seizure?"
DEREK: "Get creative. Do some research."
GEORGE: "Well, if all the normal methods have failed then what are we supposed to do-"
DEREK: "Use a strobe light. Get her drunk. Hang her up upside down from the ceiling and hit her with a wiffle ball bat, for all I care. Just make her seize. 'Cause until she seizes, I don't know when to operate, and if I don't know when to operate, I can't get this woman out of my life. And this woman is not how I like to start my mornings."

"Do girls have two pairs of panties?"

GEORGE
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Grey's Anatomy Quotes

COOPER: "It's wrong?"
NAOMI: "You need to meet a grown up. You need to date someone your own age."
VIOLET: "Someone without a porny internet name and perhaps no criminal past."
NAOMI: "A nice girl."
VIOLET: "A reliable girl."
NAOMI: "Someone who you can have a relationship with."
VIOLET: "You’re a respected doctor."
NAOMI: "Go out in the real world. Meet a woman your own age and go out."
VIOLET: "Be a man."

ADDISON: "You work with your ex-husband in a shrine for your ex-husband."
NAOMI: "It’s actually a good book. And we're friends. And we stayed friends after we divorced. It’s very healthy. We're healthy."
ADDISON: "What happened between you and Sam?"
NAOMI: "Addison, you and I were close in med school, but it was a long time ago."
ADDISON: "Oh, Naomi. Come on. You can’t stay mad at me forever. I know you."