Dude ...

Alex Karev is unmoved by Izzie's confessions of having sex with Denny.
Rating: 5.0 / 5.0

Four Residents

In a photo from "Brave New World," from Season 5, Meredith, Izzie, Cristina and Alex look on during a typical day at the hospital.
Rating: 5.0 / 5.0

Couch Sitters

It may be a "Brave New World" in Season Five of Grey's Anatomy for Meredith, Cristina and Izzie, but there's still time for some lighter moments. In this case, sitting on a couch!
Rating: 5.0 / 5.0

Breaking Point

A photo from the fourth season finale of Grey's Anatomy, "Freedom." Izzie Stevens has reached yet another professional and personal crossroads.
Rating: 5.0 / 5.0

It's Just Izzie

Dr. Izzie Stevens (Katherine Heigl) is all smiles in this promotional photo for "These Ties That Bind," from the turbulent but terrific fifth season of Grey's Anatomy.
Rating: 5.0 / 5.0

Mother and Daughter (Izzie)

Izzie's mom makes her first appearance on Grey's Anatomy. Somehow we imagine this is not going to go swimmingly for our girl.
Rating: 5.0 / 5.0

Isobel and Her Mom

Izzie's mom makes an appearance in "No Good at Saying Sorry," the April 30 episode of Grey's Anatomy, and Izzie is not looking altogether thrilled in this picture at least.
Rating: 5.0 / 5.0

Yang Out Front

Cristina is always out to get ahead, and here she is up to her old tricks yet again in this photo from "There's No 'I' in Team," from Season Five of Grey's Anatomy.
Rating: 5.0 / 5.0

Isobel and Mark

In a still shot from "Losing My Mind," from the fourth season of Grey's Anatomy, Mark and Izzie have a serious conversation at Seattle Grace.
Rating: 5.0 / 5.0

Arrrrrrrgh

Dr. Izzie Stevens treats a hurting patient, who is wearning a look of concern (and searing pain) in this still shot from "Where The Wild Things Are," in Season Four of Grey's Anatomy.
Rating: 5.0 / 5.0

Izzie on the Scene

Izzie Stevens attends to a car crash victim (or so it would appear) in the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me."
Rating: 5.0 / 5.0

Isobel Stevens

Grey's Anatomy doctor Isobel Stevens, better known as Izzie Stevens and played by Katherine Heigl, has yet another run-in with her late fiance, Denny.
Rating: 5.0 / 5.0

Grey's Anatomy Quotes

COOPER: "It's wrong?"
NAOMI: "You need to meet a grown up. You need to date someone your own age."
VIOLET: "Someone without a porny internet name and perhaps no criminal past."
NAOMI: "A nice girl."
VIOLET: "A reliable girl."
NAOMI: "Someone who you can have a relationship with."
VIOLET: "You’re a respected doctor."
NAOMI: "Go out in the real world. Meet a woman your own age and go out."
VIOLET: "Be a man."

ADDISON: "You work with your ex-husband in a shrine for your ex-husband."
NAOMI: "It’s actually a good book. And we're friends. And we stayed friends after we divorced. It’s very healthy. We're healthy."
ADDISON: "What happened between you and Sam?"
NAOMI: "Addison, you and I were close in med school, but it was a long time ago."
ADDISON: "Oh, Naomi. Come on. You can’t stay mad at me forever. I know you."