Callie Torres and Mark Sloan made some love in the on-call room. But surprisingly, Mark later gave her the cold shoulder.
In this photo from "Piece of My Heart," Dr. Mark Sloan (Eric Dane) enjoys a smile at the expense of his friend Derek Shepherd, who's surrounded by all sorts of women he has complicated histories with.
In this photo from "Piece of My Heart," Dr. Derek Shepherd (Patrick Dempsey) gets clowned on my Dr. Mark Sloan (Eric Dane) for the awkwardness of this elevator ride.
Always a fan favorite, Mark Sloan poses for the camera.
Lexie Grey might be onto something with this new look. But seriously folks - that's a lot of blood Nick lost. The doctors tried in vain to save him but it was a lost cause at the end.
Erica Hahn puts Mark Sloan in his place awfully quickly at Joe's when he tries to act upon his "thing" for her.
Dr. Erica Hahn (Brooke Smith) sizes up her sexy surgeon counterparts Derek Shepherd (Patrick Dempsey) and Mark Sloan (Eric Dane). Gotta love these three together!
Derek and Mark used to be best friends. Slowly they've been building that back up. Can it be back to the old days again?
They do their thing, as always! Mark, Izzie and Callie tend to a patient played by guest star Ben Vereen in an early Season Four episode of "Grey's Anatomy."
Mark Sloan (Eric Dane) shows us a rare smile in an early episode of Season Four of Grey's Anatomy. Hopefully this fellow will be smiling more in this exciting new campaign.
The Season Four cast of Grey's Anatomy: Starring the lovely Ellen Pompeo (Meredith Grey), Patrick Dempsey (Derek Shepherd), Sandra Oh (Cristina Yang), Katherine Heigl (Izzie Stevens), T.R. Knight (George O’Malley), Justin Chambers (Alex Karev), Chandra Wilson (Miranda Bailey), James Pickens, Jr. (Richard Webber), Sara Ramirez (Callie Torres), Eric Dane (Mark Sloan) and Chyler Leigh (Lexie Grey).
Mark Sloan won't be Chief, but he made the rest of the candidates vying for it work harder.

Grey's Anatomy Quotes

Did you say it? 'I love you. I don't ever want to live without you. You changed my life.' Did you say it? Make a plan. Set a goal. Work toward it, but every now and then, look around; Drink it in 'cause this is it. It might all be gone tomorrow."

Meredith (closing voiceover)

Lexie: [narrating] Grief may be a thing we all have in common, but it looks different on everyone.
Mark: It isn't just death we have to grieve. It's life. It's loss. It's change.
Alex: And when we wonder why it has to suck so much sometimes, has to hurt so bad. The thing we gotta try to remember is that it can turn on a dime.
Izzie: That's how you stay alive. When it hurts so much you can't breathe, that's how you survive.
Derek: By remembering that one day, somehow, impossibly, you won't feel this way. It won't hurt this much.
Bailey: Grief comes in its own time for everyone, in its own way.
Owen: So the best we can do, the best anyone can do, is try for honesty.
Meredith: The really crappy thing, the very worst part of grief is that you can't control it.
Arizona: The best we can do is try to let ourselves feel it when it comes.
Callie: And let it go when we can.
Meredith: The very worst part is that the minute you think you're past it, it starts all over again.
Cristina: And always, every time, it takes your breath away.
Meredith: There are five stages of grief. They look different on all of us, but there are always five.
Alex: Denial.
Derek: Anger.
Bailey: Bargaining.
Lexie: Depression.
Richard: Acceptance.