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Greys-anatomy
Meredith & Derek
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The only couple on this list who actually hooked up prior to the series ever starting, Grey's Anatomy kicked off the morning after Meredith and Derek went home from a bar together. Sure, he was married at the time - but that technicality was no match in the end for (sorry we have to say it...) the McDreamiest pairing on all of television.

Rating: 5.0 / 5.0 (68 Votes)

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