The predator drone on Chuck is being controlled by Orion's laptop which fell into the hands of the always competent Jeff, Lester and Morgan.
Added:

Chuck Season 2 Episode 17 Quotes

(Chuck watches surveillance of Sarah, Casey and General Beckman)
Chuck: Wow. Beckman is tiny.
Sarah: General, what if Orion can help Chuck remove the Intersect? Erase it from his mind?
Chuck: Yeah, yeah. Good question, Sarah.
Beckman: That's exactly what I don't want. Chuck Bartowski is absolutely vital to national security. He can never meet Orion.

This disc will self-destruct in five seconds. I've always wanted to say that.

Orion