Meredith and Derek look great in this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," but is tragedy about to strike Derek? We hope not...

We're just saying. Meredith and Derek are awesome in this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me." We're just hoping this isn't it.

Is it just us or is Cristina flashing a smile in this photo? It would be some time since she had, so we are all for it.

We are digging Callie this season. We just gotta put that out there. Girl looks damn good.

Cristina and Callie talk to a patient in this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me." We'll see what develops between these two this year.

Kevin McKidd guest stars as Dr. Owen Hunt in this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me."

Derek Shepherd flashes that familiar smile and makes us melt in this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me."

Derek Shepherd looks contemplative in this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me."

In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," an intense Dr. Derek Shepherd (Patrick Dempsey) appears to be getting more and more caught up in a really heated discussion with Dr. Owen Hunt (Kevin McKidd).

In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Dr. Derek Shepherd (Patrick Dempsey) appears to be in a heated debate with Dr. Owen Hunt (Kevin McKidd).

In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," guest star Bernadette Peters is sandwiched between ex-spouses George (TR Knight) and Callie (Sara Ramirez).

In this photo from the Season 5 premiere of Grey's Anatomy, "Dream a Little Dream of Me," Callie tends to a patient who appears to be making a phone call. We're not experts but that's gotta be against some kind of policy. No?