What was the most painful Grey's Anatomy death?

Grey's Anatomy has featured MANY huge deaths over the years. Which hurts the most?

Derek Says Goodbye - Grey's Anatomy Season 11 Episode 21
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Grey's Anatomy Quotes

[walking by Izzie's room]
Meredith: Hot.
Sadie: Horny.

Sexual sorbet? Hahaha! I love it.

Bailey

Grey's Anatomy Music

  Song Artist
You Know I'm No Good Amy Winehouse iTunes
Song Worrisome Heart Melody Gardot
Help I'm Alive Metric iTunes

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Grey's Anatomy Promo: Meredith Does Community Service!
Grey's Anatomy Season Finale Promo: DeLuca in Cuffs!
Grey's Anatomy Promo: Rom-Com Goodness!
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