Patrick Dempsey explains the remarks he made to Italian Vanity Fair in this interview with David Letterman. He doesn't really make his Grey's Anatomy situation much clearer, though.

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please dont leave patrick dempsey... Grey's wouldnt be grey's without you and Meredith...Laila of the Philippines

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Grey's Anatomy Quotes

Just because we can live without something, it doesn't mean we have to.

Meredith

Derek: I am calling post-it, Zola, Bailey, the tumors on the wall, ferryboat scrub caps. I thought D.C. was everything. I was wrong. You... you're everything. I love you and I'm not going to stop loving you. I can't live without you. I don't want to live without you, and I'm going to do everything in my power to prove it.
Meredith: I can live without you, but I don't want to. I don't ever want to.