What they may not know is that the story line hits particularly close to home for star Isaiah Washington, who plays Dr. Burke.
The 43-year-old actor recently told TV Guide about the personal memories triggered by the season-ending shooting of his character.
Washington was a victim of gun violence in his early years but is only now talking about it publicly. He tells the magazine: "I was young and dumb and one day I popped my mouth to the wrong person and got shot."
On an episode of Judge Hatchett, Washington told his story to a troubled teen in an effort to send him down the right path.
"Somebody tried to take my life. I have a bullet hole in my right hip from being shot," Washington said. "I thought I was smarter and faster and quicker than the person I was waiting for at the age of 19. I'm 43 and there was a time where I thought I'd never see 25."
Washington hopes his decision to come forward with his story will help this youngster and others choose a more positive path.
"He needed to see that we all have a choice in this world, that we can all change our destiny," Isaiah said.
Washington has made a career as a talented actor, but more impressively, he continues to leave an idelible mark as a human being dedicated to worthy causes and promoting the common good.