When Rita was killed off Dexter to conclude season four, it "changed the formula of the show," star Jennifer Carpenter says in the following video.

Now, as the actress who plays Deb previews, "anything could happen."

Below, various cast members dish on the effects his wife's murder will have on Dexter Morgan, as fans get their first glimpses at scenes from the new season. It premieres on September 26 and you can check out photos from the episode NOW. Watch and enjoy:

[video url="http://www.tvfanatic.com/videos/dexter-season-premiere-clip/" title="Dexter Season Premiere Clip"][/video]

Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.